An evaluation of the Invisalign® Aligner Technique and consideration of the force system: a systematic review

Objective Since its introduction 25 years ago, the Invisalign® system has undergone multiple digital and biomechanical evolutions and its effectiveness is often compared to traditional systems without considering the many differences which characterize them. The main aim of this systematic review is to look at the literature dealing with studies on teeth movements using the Invisalign® system and the management of these movements through digital planning and artificial intelligence. Materials and methods The following electronic databases were searched: MEDLINE, Embase, the Cochrane Oral Health Group’s Trials Register, and CENTRAL. Unpublished studies were searched on ClinicalTrials.gov, the National Research Register, and Pro-Quest Dissertation Abstracts and Thesis database. Results Twenty-four studies (15 retrospective, 5 prospective, 2 pilot, and 2 case–control) were included. The results of the analysis carried out on the available literature show that the Invisalign® system is recognized to be a valid alternative to conventional orthodontic treatment in no-extraction cases. The results are influenced by the methods for assessing the effectiveness of this technique and by the comparison bias of the traditional system with the innovative digital system. Conclusions Since the introduction of SmartForce and SmartTrack material, the efficacy of the treatment has improved. There is still a shortage of high-quality evidence concerning the treatment modality. In order to make the treatment with the aligners more efficient, a correct management of the ClinCheck® software and a proper use of the biomechanics are necessary. The aligned force-driven system should be taken into account when developing the digital planning.


Introduction
In 1997, two students from the University of Stanford revolutionized the way we have been practicing orthodontics by introducing the Invisalign ® system which uses digital software to plan dental movements making them possible by using clear aligners which have replaced traditional brackets.
The aligners have proved to be an increasingly widespread solution for adults and growing patients who express the desire to resort to aesthetic and comfortable alternatives to the use of conventional fixed appliances.The adverse effects of traditional orthodontics, like periodontal diseases, are minimized by using a removable device which also allows patients to easily perform oral hygiene procedures [1,2].
If compared to fixed orthodontic appliances, the greatest advantage of the clear aligner is the improvement of aesthetics and comfort for the patient.Furthermore, it is possible to control the force system of the tooth movements and manage them in a more accurate way thanks to the ClinCheck ® software.
Notwithstanding the existence of a large body of literature related to the Invisalign ® technology, a comprehensive study of its clinical performance has not yet been carried out and a synthesis of the evidence is lacking.Three systematic reviews on the accuracy and predictability of treatment with the Clear Aligners System have assessed the evidence related to the efficacy of clear aligner treatment (CAT) in controlling orthodontic tooth movement; however, these reviews date back to 2015, 2017, and 2018, respectively [3][4][5].Further reviews have compared CAT with conventional brackets [6] and assessed the prediction of rotational tooth movements with aligners [7].Because of the continuous improvement of the Invisalign ® system and since reviews include studies that analyze different types of aligners, the findings should be interpreted with some caution.The two most notable innovations are the introduction of SmartForce features (2008), such as optimized attachments, pressure zones, and customized staging, and the SmartTrack aligner material (2011) which allows for a better range of force delivery and fit.
Therefore, the purpose of the present review is to reevaluate the effectiveness of this treatment system by only considering research using the latest updates of the Invisalign ® system.
Moreover, another aspect of this review is to introduce the concept that the aligned force-driven system should be taken into account when developing the digital planning.The teeth movements that occur are due to the combination of a pure mechanic movement together with a release of differential forces based on the extent and kind of correction.

Ethics
Ethics research ethics committee (REC) approval was not required for this review.

Registration and reporting
The systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines.

Search strategy
Detailed search strategies were developed and appropriately revised for each database, considering the differences in controlled vocabulary and syntax rules by the first author (S.C).The following electronic databases were searched: MEDLINE (via Ovid and PubMed, Appendix, from 1946 to August 28, 2017), Embase (via Ovid), the Cochrane Oral Health Group's Trials Register, and CENTRAL.Unpublished studies were searched on ClinicalTrials.gov, the National Research Register, Pro-Quest Dissertation Abstracts, and Thesis database.The search attempted to identify all relevant studies irrespective of language.The reference lists of all eligible studies were examined for additional studies.A manual search was thoroughly performed to identify additional articles in the references of selected articles.
A systematic search in the medical literature, from inception to April 2023, was performed to identify all peer-reviewed articles potentially relevant to the review's question.Our search strategy below was designed by an experienced information specialist.

Types of studies
Articles were included if they evaluated the predictability of teeth movement with clear aligners or if aligner treatment outcome was compared to fixed appliance therapy.Randomized clinical trials (RCTs), controlled clinical trials (CCTs), and prospective and retrospective studies were considered eligible for inclusion in this review.Case reports, in vitro studies, author's letters, and studies with surgical interventions were excluded.

PICOs
The review was conducted based on the Population, Inclusion, Comparison, Outcome (PICOs) format: "Is the Invisalign ® System effective in performing orthodontic movements if compared with fixed orthodontic appliance or with teeth movement planned on the ClinCheck ® software?(Table 1).

Population
Orthodontic adult patients (≥ 18 years of age) who were treated with Invisalign ® either as the intervention or as the control group.

Intervention and comparators
The Invisalign ® treatment was compared both to fixed orthodontic appliances and to predicted tooth movement based on ClinCheck ® Software.All other aligner systems have been excluded.

Outcome
Any result on clinical efficiency, effectiveness, treatment outcomes, movement accuracy, or predicted tooth movement in ClinCheck ® software of Invisalign ® treatment, including changes in alignment or occlusion, treatment duration, and comparison with fixed appliance.

Selection of studies
Study selection was performed independently and in duplicate by two authors of the review, who were not blinded to the identity of the authors of the studies, their institutions, and the results of their research.The study selection procedure included title-reading, abstractreading, and full-text-reading stages.The calculated coefficient of agreement between the two reviewers who screened the title and abstract of the retrieved records indicated high agreement (k value = 0.87).After the exclusion of non-eligible studies, the full report of publications considered eligible for inclusion by either author was obtained and assessed independently (Fig. 1).

Data extraction and management
The first two authors performed data extraction independently and in duplicate.Disagreements were resolved by discussion with the involvement of two collaborators (the third author and the last author).Data collection forms were used to record the desired information.The following data were collected on a customized data collection form: • Author/title/year of study • Design/setting of the study

Quality assessment
The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS), an assessment scale for assessing the quality of non-randomized studies [9].

Dealing with missing data
We contacted study authors via e-mail to request missing data where necessary.In case of no response or no provision of the missing data, only the available reported data were analyzed.

Results
Twenty-four studies (15 retrospective studies, 5 prospective, 2 pilot studies, and 2 case-control) were included.Respecting the selection, comparability, and outcome criteria, four of the twenty-four analyzed studies [10][11][12][13][14][15][16][17] were awarded the maximum number of points 9/9.The lack of standardized outcome reporting, and the high amount of clinical and methodological heterogeneity across the included studies precluded the conduct of a meta-analysis in achieving pooled estimates of effects.The results from the included studies were thus reported narratively.However, there was substantial consistency among studies that the Invisalign ® system is a viable alternative to conventional orthodontic therapy in the correction of mild to moderate malocclusions in non-growing patients that do not require extraction.
Moreover, Invisalign ® aligners can predictably level, tip, and derotate teeth (except for cuspids and premolars).On the other hand, limited efficacy was identified in arch expansion through bodily tooth movement, corrections of occlusal contacts, and larger anteroposterior and vertical discrepancies.The sample size in individual studies ranged from 20 to 200, with a total of 1391 patients.Age at the start of the aligner's treatment in the evaluated samples ranged from 13 to 75 years (Table 2).

Qualitative synthesis of the included studies
Five studies [18, 22, 24, 26-28, 31, 33] reported an 8/9 points as they received ½ in the comparability criteria.Two studies [21,23,30] reported 7/9 points as they received one point in the comparability criteria and 2/3 points in the outcome criteria.Finally, three studies [11,19,20,25,29] received 6/9 points of which 2 missing in the selection criteria and one missing in the comparability criteria.All of them exceeded 5 points, and thus, they are of high quality as seen in the table (Tables 2 and 3).

Clinical findings Transverse changes
Six studies have focused attention on the efficacy and predictability of the transversal expansion with Invisalign ® .
Efficacy In 2011, Pavoni et al. showed that the Invisalign ® group, made of 20 participants, had a statistically significant increase in transverse dimension: second interpremolar width at the fossa point (0.45 mm), intermolar widths at the fossa (0.50 mm), and canine cusp width (0.50 mm).Nevertheless, these values are lower than the ones from the self-ligating group (20 patients), exactly 2.50 mm for the fossa point, and 0.90 mm for intermolar widths.Moreover, a significant difference was found between the two groups for the intercanine widths, and the change at the cusp was significantly larger in the self-ligating group (2.65 mm) [26].
A study with sixty-one patients of The results revealed that buccal arch expansion played a significant role in crowding management [27].
Grunheid et al. assessed the buccolingual inclination of mandibular canines and their intercanine distance in sixty patients treated with clear aligner (30) and fixed appliance (30).The buccolingual inclination was greater in the aligner group than in the fixed appliance group at T2 but the canines appears more upright in the fixed appliance group [28].Zhou et al. evaluated the correlation between the amount of designed expansion and the efficiency of bodily expansion.The efficiency of expansion decreased from the canine to the first molar [21].
Accuracy In the study by Houle which involved sixtyfour patients, the lingual gingival margin at the upper first molar was the area with less accuracy (52.9%).The most reliable area to predict transverse changes in the maxilla was the canine crown with 88.9% of the change achieved.
The lower arch presented an overall accuracy of 87.7%, 98.9% at the crown and 76.4% at the gingival margins [19].
In 2020, Morales-Burruezo et al. in a study involving 114 patients found that predictability was 74.8% at the canine, 80.3% at the first premolar, 81% at the second premolar, 79.1% at the first molar, and 65.2% at the second molar [18].
Zhou et al. highlighted that the average expansion efficiencies were 79.75% at the upper canine crown, 76.1% the first premolar crown, 73.27% at the second premolar crown, and 68.31% at the first molar crown [21].
Riede et al. showed that the following differences between simulated and clinical discrepancy were found in the maxillary arch: the largest undercorrection compared to the simulated goals was seen for intermolar width at the gingival margins (2.9 mm) and the largest overcorrection for intercanine width at the gingival margins (3.7 mm) [23].

Sagittal movements
In a study of 30 patients, the distalization of upper molars was the most effective movement, with an efficacy of approximately 87%.No statistically significant differences (p > 0.05) in terms of accuracy on upper molar distalization (> 1.5 mm) comparing Invisalign ® with horizontal beveled gingival attachment and Invisalign ® without auxiliaries treatments: 88.4% vs. 86.9%.In the upper arch, the premolars and molars showed the final position more distal than the planned one, whereas in the mandible, the central incisors, the second premolar, and the first molar had the same behavior [11].Ravera et al. showed that in their 20 participants, the second molar had a distal average movement of 2.52 mm measured on the mesiobuccal cusp and of 2.12 mm measured on the center of the crown, without significant tipping (P = 0.056) and vertical movements of the crown (P = 0.25).The maxillary central incisor edge was retracted by 2.23 mm (P < 0.01) without significant vertical movements (P = 0.43) and with a good control of its orientation with respect to the palatal plane (initial value 109.60°± 6.70°, post-treatment value 106.70° ± 6.66°, P < 0.05). 17Horizontal movements of all incisors seemed to be accurate, with small (0.20-0.25 mm) or insignificant differences between predicted and achieved amounts [15].
In 2019, Dai et al. in a study with 30 patients, compared achieved and predicted tooth movements of maxillary first molars and central incisors in first premolar extraction cases treated with Invisalign ® .First molars achieved greater mesial tipping, mesial translation, and intrusion than predicted.First molars were predicted to tip distally (2.94° ± 3.84°) but actually tipped mesially (2.92° ± 4.62°), with a difference of 5.86° ± 3.5°, and translated mesially 2.26 mm more than predicted [32].

Vertical movements
Krieger et al. highlighted that vertical movements were more difficult to reach than transverse or sagittal movements.The parameter overbite displayed the greatest deviations between the predicted and achieved tooth movements (− 0.71 mm) [20].
Gu et al. agreed with this assertion.Moving teeth with aligners is more difficult in the vertical than the sagittal plane, as previously suggested [16].

Intrusion
With regard to incisors, the results of the current studies resemble those of others that found movements of anterior teeth to have relatively poor accuracy; thus, significant correction of a deep overbite with Invisalign ® appears difficult.Intrusion of incisors was the most inaccurate of all linear movements.The maxillary central incisors had the greatest difference of 1.5 mm (P\0.002)[10].
In a study of 120 patients, the authors observed a 1.5-mm median opening of the overbite in the deepbite patients.The primary mechanism responsible for reducing overbite in this group seemed to be the proclination of the mandibular incisors and intrusion of the maxillary incisors.Our results suggested that the mandibular first and second molars were extruded by 0.5 mm on average.Proclination of the mandibular incisors was the main mechanism of bite opening [13].

Extrusion
In a study of 120 patients, overbite improved in all patients with pretreatment open bite, with a median deepening of 1.5 mm.Overbite correction in these patients was primarily accomplished by extrusion of the maxillary and mandibular incisors (U1-PP 5 0.9 mm, L1-MP 5 0.8 mm).Extrusion of incisors also appeared to be accurate, since no statistically significant differences were observed.The vertical canine movement seemed to be more predictable in the maxillary arch than in the mandibular arch, although the planned movement for the mandibular arch was greater [13].

Rotations
In the study by Simon et al. with 30 patients, premolar derotation showed the lowest accuracy with approximately 40% (SD = 0.3) for rotation of premolars > 10°.No statistically significant differences (p > 0.05) could be found between Invisalign ® with optimized rotation attachment and Invisalign ® without auxiliaries: 37.5% SD 0.3 vs. 42.4% SD 0.3.The results showed that the accuracy was significantly reduced for predicted rotations greater than 15°.Also, the staging had a considerable impact on the treatment efficacy: for rotations with a planned staging > 1.5°/aligner the accuracy was 23% whereas with a staging < 1.5°/aligner the total efficacy was 41.8% [11].
In 2020, Morales-Burruezo et al. showed that virtual planning overestimated the value obtained at the upper right first molar (with a difference close to statistical significance), which corresponded to the real outcome for the upper left first molar.A difference of 2.22 ± 4.37° on the right side and 2.46 ± 3.75° on the left side was identified [18].
All achieved rotations were significantly smaller than those predicted, with the maxillary canines exhibiting the greatest difference of 3.05 (P\0.001)[31].

Buccolingual movements
Torque In the study by Morales-Burruezo, the results indicated that Invisalign ® might not sufficiently produce root torque, especially in the posterior region where the buccolingual inclination is measured [18].
The difference in maxillary central incisor torque found in the current sample was consistent with other studies that observed tipping of incisors rather than bodily movement.In the upper arch, the central and lateral incisors showed a more lingual crown torque than the planned one.Maxillary posterior teeth were positioned more lingual with more facial crown torque than predicted.It is likely that maxillary arch expansion was not fully achieved and the molars tipped rather than moved bodily during the process, both of which could have resulted from flexing of the aligners.The mandibular molars also had more facial crown torque than predicted.This, too, could be the consequence of an inability of the aligners to fully express the torque specified in the virtual treatment plan and may have been compounded by biological limitations such as the proximity of the molar roots to the cortical plate of the mandible [10].
Although previous studies showed that root torque is difficult to control using aligners (especially in the posterior region when compared with the fixed appliances), our results indicated that the buccolingual inclination score was significantly improved after treatment with Invisalign ® [28].
In a split-mouth study, the efficacy of orthodontic movements either with or without attachment/power ridge was evaluated.The mean accuracy for upper incisor torque was 42% (SD = 0.2) [11].
No statistically significant differences (p > 0.05) in terms of accuracy between planned and clinically obtained movements were found (upper medial incisor torque > 10°), comparing intervention (Invisalign ® with horizontal ellipsoid attachments) and control (Invisalign ® with power bridges) treatments: 51.5% SD 0.2 vs. 49.1%SD0.2.The 11^SnaSnp and 11^Ocl angles showed the highest numeric changes with conventional brackets.The lowest data were reported with aligners [5.13 and 4.60°, respectively].Conclusions stated that the differences among these techniques were not significant for both angles [33].
Proclination According to Krieger et al., the combination of IPR and incisor protrusion was the main way to correct incisor crowding in 58% of patients [20].
In their retrospective study with 61 patients, Duncan et al. showed that in a more severely crowded dentition, the Invisalign ® treatment caused the lower incisor proclination.Lower incisor position and angulation changes were statistically significant in the severe crowding group, but not in the mild and moderate crowding groups [27].
According to the study of Hennessy et al., Invisalign ® produced a mean proclination of 3.4 ± 3.2° with respect to fixed appliances which produced 5.3 ± 4.3° of mandibular incisor proclination [30].
Central incisors achieved less retraction and greater lingual crown torque and extrusion than predicted.With regard to upper incisors, in a study on extraction cases with Invisalign ® , central incisors tipped more lingually by 5.16° and retracted less by 2.12 mm relative to predicted changes [32].

Alignment
PAR index Statistically significant anterior dental crowding improvements (p < 0.05) were found both in intervention and control groups in terms of PAR index (22.5 SD 7 to 3.5 SD 3 and 24 SD 6 to 4.5 SD4, respectively) [14].
Both intervention and control groups achieved a statistically significant clinical improvement of PAR index (> 30% of score reduction) (p < 0.05).Fixed orthodontic appliance was better than Invisalign ® at resolving malocclusion based on PAR index scores (OR 0.33 95%CI 0.13-0.815,p = 0.015).A fixed orthodontic appliance was more effective than Invisalign ® in reducing the mean percentage of PAR index (p = 0.0032).Invisalign ® treatment was faster than fixed orthodontic appliance: 13.35 vs 19.08 months, p = 0.004 [16].
Little index Statistically significant dental crowding improvements (p < 0.05) were also found in terms of the Little irregularity index obtaining a perfect alignment in 92 to 100% of cases in the intervention group and in 88 to 100% of cases in the control group.In Krieger's work, crowding reduction occurred from 5.39 to 1.57 mm (minimum 0 mm, maximum 4.5 mm) in the upper jaw and from 5.96 to 0.82 mm (minimum 0 mm, maximum 2.50 mm) in the lower jaw.The difference between achieved/predicted tooth movements ranged on average from 0.01 mm (SD ± 0.48) for the lower anterior arch length up to 0.7 mm (SD ± 0.87) for the overbite.All parameters were significantly equivalent except for the overbite (− 1.02, − 0.39) [20].

Accuracy
In 2009, Kravitz et al. evaluated the efficacy of anterior tooth movement with Invisalign ® and reported an overall mean accuracy of 41%.The most accurate tooth movement was lingual constriction, whereas the least accurate tooth movements were incisor extrusion, followed by a mandibular canine rotation.In 2020, with a prospective clinical study of 38 patients, the mean accuracy of Invisalign ® for all tooth movements was 50%.The highest overall accuracy was achieved with a buccal-lingual crown tip (56%), whereas the lowest overall accuracy occurred with rotation (46%) [34].

Aligners' change
In an uncontrolled clinical trial of 37 participants, Drake et al. showed that a large part of the movement occurs in the first week.No significant difference over an 8-week time period was found in the amount of OTM (orthodontic tooth movement) between those who wore the same aligner for 2 weeks compared to those who changed to a new duplicate aligner after one week.The role of uncontrolled tipping and loss of anchorage complicated the progression of programmed aligners [26].
In their study with 30 participants, Chisari et al. revealed similar findings.Most tooth movement occurred in the first week of the 2-week wear cycle.Although it was not statistically significant (P = 0.06), participants with a smaller goal had a higher mean percentage of goal achieved, 62%, compared with 54% for those with a planned movement of 0.50 mm.The combined data indicate that despite having aligners programmed to move 1 central incisor 1 mm labially (0.25 mm per aligner), on average only 57% of that movement was achieved.It has been postulated that a greater percentage of tooth movement would occur if the prescription in each aligner was decreased from 0.5 to 0.25 mm.As mentioned earlier, the magnitude and direction of force placed on teeth during OTM, in addition to the length of time these forces are in place, can play critical roles in how teeth move [29].

Discussion
Over the last years, the results of studies have focused on the achievement of the Invisalign ® system in terms of mm or degrees obtained in planned movement.ClinCheck ® software is not only evaluated in the context of dental movement but also in reference to the system of forces behind it.Respecting the protocols and precise staging, dental movement is allocated in the different phases of treatment due to the use of an algorithm and through a system of forces that allows the expected movements.In the literature, although many are the systematic reviews that have evaluated the accuracy of movements with Invisalign ® , updated studies in line with the progress of this technique have to be taken into account.Evaluating the efficacy of anterior tooth movement with Invisalign ® , Kravitz et al. (2009) detected an overall mean accuracy of 41%.According to a prospective study about all tooth movements carried out in 2020, the accuracy increased up to 50%.In both studies, true incisor extrusion resulted to be the least accurate tooth movement, followed by the rotation of the mandibular canine, whereas lingual constriction was reported to be the most accurate movement.The authors suggested that combining extrusion with lingual crown tip (relative extrusion) allows more predictable movements [17,26,29,34,35].Since the buccal and lingual aspects of the crown provide the largest surface area to push, it is a logical consequence that the most predictable results are due to the bucco-lingual movements.The more flexible SmartForce aligner material together with the power ridges has brought an improved accuracy in the incisor buccal crown tip [29].Notwithstanding this, problems could arise for the second molars due to the poor aligner grip around the shorter terminal crown but also to the decreased forces on the terminal tooth within the aligner.As it concerns the rotation of rounded teeth, problems were not completely solved even though optimized attachments were used for rotational movements greater than 5°.Furthermore, the accuracy of mesial rotation (52%) was significantly better than distal rotation (37%) [29].Similar results were observed by Simon et al. and Charalampakis et al. [10,11].A further evaluation of the efficacy of premolar derotation was performed taking into consideration both the amount of tooth movement and the amount of staging planned.The results related to predicted rotations greater than 15° as well as for rotations with a planned staging > 1.5°/ aligner showed that the accuracy was significantly reduced [11].As it concerns the movement accuracy, the literature shows that it was particularly low: exactly up to 28% for mesial rotation of the mandibular first molar, a little more up to 37% for distal rotation of the maxillary canine, and 35% for the intrusion of the mandibular incisors.The last result was the same as reported by Grunheid et al.The lack of posterior anchorage may be one of the explanations for the lower accuracy of mandibular incisor intrusion.In contrast, the accuracy of the second molar intrusion (51%) was relatively high.As a consequence, it can be confirmed that Invisalign ® is more effective in bite closure, rather than bite opening [24,29,35].ClinCheck ® prediction of expansion involves more bodily movement of the teeth than can be seen clinically.Furthermore, more dental tipping was observed at the end of the treatment so it follows that a careful planning with overcorrection and other auxiliary methods of expansion which may help reduce the rate of midcourse corrections and refinements, especially in the posterior region of the maxilla is suggested [17,18,36].Duncan et al. showed that crowding in the maxillary arch is corrected using IPR in most of the cases, whereas crowding in the mandible is corrected with IPR in 30% of the cases, IPR with protrusion of the incisors in 40% of cases, and sole protrusion of the incisors in 18%.Post-Invisalign ® treatment showed that 58% of the patients had had some increase in mandibular arch length [27].A study about the recovery of space in mild crowding cases conducted in 2016 by Hennessy et al. showed that fixed appliances produced 5.3 ± 4.3° of mandibular incisor proclination whereas Invisalign ® proclined the mandibular incisors by 3.4 ± 3.2°.No statistically significant difference was detected between the two groups [30].It has to be considered that when treating crowded dentitions, in order to negate or minimize lower incisor proclination, buccal expansion(if indicated) and IPR are important clinical tools to be used [27].In conclusion, two research studies revealed that over an 8-week time period, no significant difference was found in the amount of OTM (orthodontic tooth movement) between those who wore the same aligner for 2 weeks if compared to those who changed to a new duplicate aligner after 1 week.However, the reduction in the amount of OTM detected during the second week was not due to material fatigue [26,29].

Limitations
It was not possible to carry out the meta-analysis due to the great heterogeneity of the parameters used for the same outcome for the selected studies.Therefore, for some of the outcomes (PAR Index, Little Index, Aligners Change), there are few studies which analyzed each of them.

Conclusions
Although this review included a considerable number of studies, no clear clinical recommendations can be made, based on solid scientific evidence, apart from nonextraction treatment of mild to moderate malocclusions in non-growing patients.There is still a shortage of highquality evidence concerning the treatment modality.The introduction of SmartForce and SmartTrack material has improved the efficacy of the treatment, but how studies' findings are reported is unclear.
Clinicians should consider the following indications for aligner treatment: -Expansion of the upper arch occurs through more coronal tipping than bodily movement.The predictability of coronal expansion decreases moving towards the posterior sector.
-The predictability in the deepbite correction is reduced, thus requiring greater attention in the planning of the ClinCheck ® software.It occurs mainly through the proclination of the lower incisors (relative intrusion).-Differently, in the treatment of open bite, the resolution occurs through a combination of extrusion of the incisors and lingual crown tip (relative extrusion).
-In cases of crowding, the correct management involves the combination of expansion and IPR to reduce the incisal proclination.
-In sagittal movements, it is advisable not to go beyond the 2-3 mm distalization of the molars.
-At the end of the treatment, the incisal position is almost always more occlusal than expected, the rotations of the premolars and the incisal torque are not completely resolved.
The authors want to emphasize to that almost all the published scientific literature presents biases since there is not any knowledge about the clinical level of those who use the software to plan the treatment.Moreover, the latest features of the system and the latest digital protocols are not taken into account.All things considered, it is evident that more high-quality research of prospective design focused on force system that leads to orthodontic movement in each phase of staging needs to be carried out in the future.Moreover, the major problem is that a digital biomechanics system is compared to traditional biomechanics and that the final results of the software are measured considering it as a final position to be reached and not as a system of forces to be applied.
Until the evaluation trend of the Invisalign ® system changes, the scientific literature will be limited to the evaluation of the technique itself.

Fig. 1
Fig. 1 Flow diagram for the selection of studies according to PRISMA (diagram from: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009).Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement.PLoS Med 6(7): e1000097

Table 1
A diagram to illustrate the study population, interventions and comparisons, types of study, and patient-relevant outcomes

Table 3
[22]astle-Ottawa Quality Assessment Scale (NOS) for case control and cohort studies In 2016, the average expansion obtained in 116 patients was 1.38 mm at cusp canine width, 0.54 mm at canine gingival width, 1.39 mm at first premolar gingival width, 1.25 mm at second premolar gingival width, and 0.56 mm at molar gingival width.Despite that, the expansion planned by the final ClinCheck ® software is not predictable at canine cusp and gingival width, first premolar cusp and gingival width, second premolar cusp and gingival width, molar cusp and gingival width, and canine depth[22].